The impact of HLA matching on outcomes of unmanipulated haploidentical HSCT is modulated by GVHD prophylaxis

Author:

Lorentino Francesca1ORCID,Labopin Myriam234,Fleischhauer Katharina5,Ciceri Fabio1,Mueller Carlheinz R.6,Ruggeri Annalisa234,Shimoni Avichai7,Bornhäuser Martin8,Bacigalupo Andrea9,Gülbas Zafer10,Koc Yener11,Arcese William12,Bruno Benedetto13,Tischer Johanna14,Blaise Didier15,Messina Giuseppe16,Beelen Dietrich W.17,Nagler Arnon37,Mohty Mohamad234

Affiliation:

1. Hematology and Bone Marrow Transplant Unit, San Raffaele Scientific Institute, Milan, Italy;

2. Hématologie Clinique et Thérapie Cellulaire, Hôpital Saint-Antoine, Assistance Publique–Hôpitaux de Paris, Paris, France;

3. Universitè Pierre et Marie Curie, Paris, France;

4. Unité de Recherche Mixte en Santé (UMR_S) 938, INSERM, Paris, France;

5. Institute for Experimental Cellular Therapy, University Hospital Essen, Essen, Germany;

6. German National Bone Marrow Donor Registry, Ulm, Germany;

7. Hematology Division, Chaim Sheba Medical Center, Tel Hashomer, Israel;

8. Medizinische Klinik Und Poliklinik I, Universitätsklinikum Carl Gustav Carus Der Technische Universität Dresden, Dresden, Germany;

9. Division of Hematology, Catholic University of the Sacred Heart, Rome, Italy;

10. Bone Marrow Transplantation Department, Anadolu Medical Center Hospital, Kocaeli, Turkey;

11. Hematopoietic Stem Cell Transplantation Unit, Medical Park Hospital, Antalya, Turkey;

12. Stem Cell Transplant Unit, Fondazione Policlinico Tor Vergata, Tor Vergata University, Rome, Italy;

13. Dipartimento di Ematologia, Presidio Molinette, Universitá di Torino, Turin, Italy;

14. Department of Internal Medicine III, Hematopoietic Cell Transplantation, Grosshadern Clinic, University Hospital of Munich (Ludwig Maximilians University), Munich, Germany;

15. Programme de Transplantation et Thérapie Cellulaire, Centre de Recherche en Cancérologie de Marseille, Institut Paoli Calmettes, Marseille, France;

16. Hematology and Stem Transplantation Unit, Onco-Hematology Department, Bianchi Melacrino Morelli Hospital Agency, Reggio Calabria, Italy; and

17. Department of Bone Marrow Transplantation, University Hospital, Essen, Germany

Abstract

Key Points In unmanipulated haplo-HSCT, antigenic HLA-DRB1 match, stem cell source, conditioning, and donor sex are associated with GVHD. The role of HLA-matching status and other factors influencing alloreactivity is more prominent with PTCy compared to ATG GVHD prophylaxis.

Publisher

American Society of Hematology

Subject

Hematology

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