Autoimmune hypoglycemia expands the biological spectrum of HHV8+ multicentric Castleman disease

Author:

Arnautou Pierre1,Auclair Martine2,Fellahi Soraya3ORCID,Bouché Clara4ORCID,Fieschi Claire15ORCID,Barrak Elias6,Queyrel-Moranne Viviane7,Chaillous Lucy6,Blin Nicolas6,Malphettes Marion15,Fadlallah Jehane15,Bertinchamp Remi15,Gérard Laurence15ORCID,Bengoufa Djaouida8,Galicier Lionel15,Oksenhendler Eric15ORCID,Vigouroux Corinne2910ORCID,Boutboul David1511ORCID

Affiliation:

1. Clinical Immunology Department, Hôpital Saint Louis, Université de Paris, Paris, France;

2. Sorbonne Université, INSERM UMRS_938, Saint-Antoine Research Centre, IHU ICAN, Paris, France;

3. Biochemistry Laboratory, Hôpital Henri Mondor, Créteil, France;

4. Endocrinology Department, Hôpital Lariboisière, and

5. National Reference Center for Castleman disease, Hôpital Saint Louis, Université de Paris, Paris, France;

6. Endocrinology Department, CHU Nantes, Nantes, France;

7. Rheumatology Department, CHU Nice, Nice, France;

8. Immunology and Histocompatibility Laboratory, Hôpital Saint Louis, Université de Paris, Paris, France;

9. Department of Endocrinology and

10. Department of Molecular Biology and Genetics, Assistance Publique–Hôpitaux de Paris, Saint Antoine Hospital, National Reference Centre for Rare Diseases of Insulin Secretion and Insulin Sensitivity (PRISIS), Paris, France; and

11. U976 HIPI, INSIGHT team, Hôpital Saint Louis, Université de Paris, Paris, France

Abstract

Key Points Autoimmune hypoglycemia belongs to the clinical spectrum of HHV8+ MCD and rituximab is an effective treatment of this condition. This rare complication is related to autoantibodies directed toward the insulin receptor and activating the insulin signaling pathway.

Publisher

American Society of Hematology

Subject

Hematology

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