Mutational dynamics of early and late relapsed childhood ALL: rapid clonal expansion and long-term dormancy-Reference-Cited by-同舟云学术

Mutational dynamics of early and late relapsed childhood ALL: rapid clonal expansion and long-term dormancy

Published:2018-01-25 Issue:3 Volume:2 Page:177-188
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Spinella Jean-François¹,Richer Chantal¹,Cassart Pauline¹,Ouimet Manon¹,Healy Jasmine¹,Sinnett Daniel¹²

Affiliation:

1. CHU Sainte-Justine Research Center and

2. Department of Pediatrics, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.

Abstract

Key Points Two distinct evolutionary patterns govern early and late relapse. Evolutionary patterns suggest a mutation-driven resistance for early relapses and a re-expansion of dormant cells for late ones.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/2/3/177/880092/advances011510.pdf

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