Novel SF3B1 in-frame deletions result in aberrant RNA splicing in CLL patients-Reference-Cited by-同舟云学术

Novel SF3B1 in-frame deletions result in aberrant RNA splicing in CLL patients

Published:2017-06-14 Issue:15 Volume:1 Page:995-1000
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Agrawal Anant A.¹,Seiler Michael¹,Brinton Lindsey T.²,Mantel Rose²,Lapalombella Rosa²,Woyach Jennifer A.²,Johnson Amy J.²,Zhu Ping¹,Warmuth Markus¹,Yu Lihua¹,Byrd John C.²,Smith Peter G.¹,Blachly James S.²,Buonamici Silvia¹

Affiliation:

1. H3 Biomedicine, Inc., Cambridge, MA; and

2. Ohio State University Comprehensive Cancer Center, Columbus, OH

Abstract

Key Points We identify and characterize novel SF3B1 in-frame deletions in chronic lymphocytic leukemia. These deletions are functionally similar to well-known SF3B1 hotspot mutations and are sensitive to splicing modulation.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/15/995/878649/advances007062.pdf

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