GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets-Reference-Cited by-同舟云学术

GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets

Published:2020-01-03 Issue:1 Volume:4 Page:76-86
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Chen Xi¹^ORCID,Gupta Shuchi²³^ORCID,Cooper Matthew¹^ORCID,DeHelian Daniel²³^ORCID,Zhao Xuefei¹⁴,Naik Meghna U.¹,Wurtzel Jeremy G. T.¹,Stalker Timothy J.²³,Goldfinger Lawrence E.¹^ORCID,Benovic Jeffrey⁵,Brass Lawrence F.²³^ORCID,McKenzie Steven E.¹,Naik Ulhas P.¹,Ma Peisong¹^ORCID

Affiliation:

1. Cardeza Foundation for Hematologic Research, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA;

2. Department of Medicine and

3. Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA;

4. Cyrus Tang Hematology Center, Soochow University, Suzhou, China; and

5. Department of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA

Abstract

Key pointsGRK6 regulates the hemostatic response by limiting platelet activation via thrombin and adenosine 5′-diphosphate. GRK6 regulates the hemostatic response by reducing PAR1/4- and P2Y12-dependent signaling.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/4/1/76/1550853/advancesadv2019000467.pdf

Reference45 articles.

1. Negative regulators of platelet activation and adhesion;Stefanini;J Thromb Haemost,2018

2. Desensitization of G protein-coupled receptors;Freedman;Recent Prog Horm Res,1996

3. The role of receptor kinases and arrestins in G protein-coupled receptor regulation;Krupnick;Annu Rev Pharmacol Toxicol,1998

4. G protein-coupled receptor kinases: past, present and future;Komolov;Cell Signal,2018

5. Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases;Penela;Cell Signal,2003

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