Enhancing functional platelet release in vivo from in vitro–grown megakaryocytes using small molecule inhibitors-Reference-Cited by-同舟云学术

Enhancing functional platelet release in vivo from in vitro–grown megakaryocytes using small molecule inhibitors

Published:2018-03-15 Issue:6 Volume:2 Page:597-606
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Jarocha Danuta¹,Vo Karen K.¹²,Lyde Randolph B.¹²,Hayes Vincent¹,Camire Rodney M.³⁴,Poncz Mortimer¹³

Affiliation:

1. Division of Hematology, Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA;

2. Department of Pharmacology and

3. Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; and

4. Center for Cellular and Molecular Therapeutics, Children’s Hospital of Philadelphia, Philadelphia, PA

Abstract

Key PointsDrugs shown to enhance megakaryocyte ploidy and size variably effect terminal injury and apoptosis of in vitro–grown megakaryocytes. The number of functional platelets released in vivo from infused megakaryocytes can be enhanced by these drug treatments.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/2/6/597/882829/advances010975.pdf

Reference48 articles.

1. Why has demand for platelet components increased? A review;Estcourt;Transfus Med,2014

2. Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development;Kaushansky;Proc Natl Acad Sci USA,1995

3. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo;Lok;Nature,1994

4. The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production;Kuter;Proc Natl Acad Sci USA,1994

5. Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional;Choi;Blood,1995

Cited by 21 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Packaging of supplemented urokinase into alpha granules of in vitro–grown megakaryocytes for targeted nascent clot lysis;Blood Advances;2024-07-12

2. Packaging of supplemented urokinase into naked alpha-granules ofin vitro-grown megakaryocytes for targeted therapeutic delivery;2023-12-05

3. Massively parallel base editing to map variant effects in human hematopoiesis;Cell;2023-05

4. Baffled‐flow culture system enables the mass production of megakaryocytes from human embryonic stem cells by enhancing mitochondrial function;Cell Proliferation;2023-04-23

5. RUNX1-deficient human megakaryocytes demonstrate thrombopoietic and platelet half-life and functional defects;Blood;2023-01-19