In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function-Reference-Cited by-同舟云学术

In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function

Published:2017-06-05 Issue:14 Volume:1 Page:918-932
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Durrant Tom N.¹^ORCID,Hutchinson James L.¹,Heesom Kate J.²,Anderson Karen E.³^ORCID,Stephens Len R.³,Hawkins Phillip T.³,Marshall Aaron J.⁴⁵^ORCID,Moore Samantha F.¹^ORCID,Hers Ingeborg¹^ORCID

Affiliation:

1. School of Physiology, Pharmacology and Neuroscience and

2. Proteomics Facility, University of Bristol, Bristol, United Kingdom;

3. Signalling Programme, Babraham Institute, Cambridge, United Kingdom; and

4. Department of Immunology and

5. Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba, Winnipeg, MB, Canada

Abstract

Key Points We present the first in-depth analysis of platelet PtdIns(3,4,5)P3-binding proteins, providing a valuable resource for future studies. The PtdIns(3,4,5)P3-binding protein, DAPP1, negatively regulates glycoprotein VI–driven platelet activation and thrombus formation.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/14/918/877319/advances005173.pdf

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