Total metabolic tumor volume, circulating tumor cells, cell-free DNA: distinct prognostic value in follicular lymphoma

Author:

Delfau-Larue Marie-Hélène1234ORCID,van der Gucht Axel35,Dupuis Jehan46,Jais Jean-Philippe47,Nel Isabelle1,Beldi-Ferchiou Asma13,Hamdane Salma1,Benmaad Ichrafe1,Laboure Gaelle6,Verret Benjamin6,Haioun Corinne2346,Copie-Bergman Christiane2348,Berriolo-Riedinger Alina49,Robert Philippine10,Casasnovas René-Olivier410,Itti Emmanuel345

Affiliation:

1. Hematologic and Immunologic Biology Department, Assistance Publique Hôpitaux de Paris, HU Henri Mondor, Créteil, France;

2. INSERM U955 Team 9, Créteil, France;

3. Paris-Est Créteil University, Créteil, France;

4. Lymphoma Study Association, Pierre-Benite, France;

5. Nuclear Medicine Department and

6. Lymphoid Hemopathy Unit, Assistance Publique Hôpitaux de Paris, HU Henri Mondor, Créteil, France;

7. Biostatistics Department, Assistance Publique Hôpitaux de Paris, Necker, Paris, France;

8. Pathology Department, Assistance Publique Hôpitaux de Paris, HU Henri Mondor, Créteil, France;

9. Nuclear Medicine Department, Centre GF Leclerc, Dijon, France; and

10. Department of Clinical Hematology, CHU Le Bocage and INSERM UMR1231, Dijon, France

Abstract

Key Points Cell-free DNA and circulating tumor cells are related to TMTV in follicular lymphoma at diagnosis. Cell-free DNA levels, in addition to TMTV, define high-risk follicular lymphoma patients.

Publisher

American Society of Hematology

Subject

Hematology

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