Low fetal hemoglobin percentage is associated with silent brain lesions in adults with homozygous sickle cell disease-Reference-Cited by-同舟云学术

Low fetal hemoglobin percentage is associated with silent brain lesions in adults with homozygous sickle cell disease

Published:2017-12-01 Issue:26 Volume:1 Page:2503-2509
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Calvet David¹,Tuilier Titien²,Mélé Nicolas¹,Turc Guillaume¹,Habibi Anoosha³,Abdallah Nassim Ait³,Majhadi Loubna⁴,Hemery François⁵,Edjlali Myriam⁶,Galacteros Frédéric³,Bartolucci Pablo³

Affiliation:

1. Service de Neurologie, Centre Hospitalier Sainte-Anne, Université Paris Descartes, Département Hospitalo-Universitaire (DHU) Neurovasc Sorbonne Paris Cité, INSERM U894, Paris, France;

2. Service de Neuroradiologie, Hôpital Henri-Mondor, Université Paris-Est Créteil (UPEC), Créteil, France;

3. Sickle Cell Referral Center, Service de Médecine Interne, Hôpital Henri-Mondor (Assistance Publique–Hôpitaux de Paris [APHP]), UPEC, INSERM U895, Team 2, Laboratoire d’Excellence GRex, Créteil, France;

4. Service de Neurologie, Hôpital Henri-Mondor, UPEC, Créteil, France;

5. Département Informatique Médicale, Hôpital Henri-Mondor (APHP), Créteil, France; and

6. Service de Neuroradiologie, Centre Hospitalier Sainte-Anne, Université Paris Descartes, DHU Neurovasc Sorbonne Paris Cité, INSERM U894, Paris, France

Abstract

Key Points Low %HbF is independently associated with silent WMCs on brain imaging in adults with SCD. Our results highlight the potential use of therapeutic strategies inducing HbF expression in SCD patients with silent white matter changes.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/26/2503/879973/advances005504.pdf

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