Sptlc1 is essential for myeloid differentiation and hematopoietic homeostasis-Reference-Cited by-同舟云学术

Sptlc1 is essential for myeloid differentiation and hematopoietic homeostasis

Published:2019-11-21 Issue:22 Volume:3 Page:3635-3649
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Parthibane Velayoudame¹,Acharya Diwash¹,Srideshikan Sargur Madabushi¹,Lin Jing¹,Myerscough Dru G.¹,Abimannan Thiruvaimozhi¹,Vijaykrishna Nagampalli²³^ORCID,Blankenberg Daniel²³^ORCID,Bondada Lavanya¹,Klarmann Kimberly D.⁴,Fox Stephen D.⁵,Andresson Thorkell⁵,Tessarollo Lino⁴,Acharya Usha¹⁶,Keller Jonathan R.⁴,Acharya Jairaj K.¹^ORCID

Affiliation:

1. Cancer and Developmental Biology Laboratory, National Cancer Institute, National Institutes of Health, Frederick, MD;

2. Genomic Medicine Institute and

3. Lerner Research Institute, Cleveland Clinic, Cleveland, OH;

4. Mouse Cancer Genetics Program and

5. Mass Spectrometry Group, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD; and

6. Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA

Abstract

Key PointsSptlc1 is essential for myeloid differentiation during hematopoiesis; ER stress prevents myeloid development in Sptlc1 mutant mice. Accumulation of fatty acid promotes ER stress in Sptlc1 mutant myeloid progenitors.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/3/22/3635/1542516/advancesadv2019000729.pdf

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