Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series

Author:

Wise Jillian F.12345ORCID,Nakken Sigve2678ORCID,Steen Chloé B.19ORCID,Vodák Daniel267ORCID,Trøen Gunhild10,Johannessen Bjarne711,Lingjærde Ole Christian9,Hilden Vera13,Blaker Yngvild Nuvin137,Bai Baoyan13,Aasheim Lars Birger26,Pasanen Annika1213,Lorenz Susanne2614ORCID,Sveen Anita711,Lothe Ragnhild A.2711,Myklebost Ola2615ORCID,Leppä Sirpa1213ORCID,Meza-Zepeda Leonardo A.2614ORCID,Beiske Klaus710,Lawrence Michael S.4516,Hovig Eivind269ORCID,Myklebust June Helen13,Smeland Erlend B.123,Holte Harald2317ORCID

Affiliation:

1. Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway;

2. Norwegian Cancer Genomics Consortium, Oslo, Norway;

3. K. G. Jebsen Centre for B-cell Malignancies, Faculty of Medicine, University of Oslo, Oslo, Norway;

4. Massachusetts General Hospital Cancer Center, Boston, MA;

5. Department of Pathology, Harvard Medical School, Charlestown, MA;

6. Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway;

7. Institute of Clinical Medicine, Faculty of Medicine,

8. Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, and

9. Department of Informatics, University of Oslo, Oslo, Norway;

10. Department of Pathology and

11. Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway;

12. Department of Oncology, Helsinki University Hospital Cancer Center, Helsinki, Finland;

13. Research Program Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland;

14. Genomics Core Facility, Department of Core Facilities, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway;

15. Department for Clinical Science, University of Bergen, Bergen, Norway; and

16. Broad Institute of Harvard and MIT, Cambridge, MA;

17. Department of Oncology, Oslo University Hospital, Oslo, Norway

Abstract

Key Points Diagnostic and relapse diffuse large B-cell lymphoma (DLBCL) biopsies reveal increased mutational burden/loss of heterozygosity in HLA-A. Serially sampled tumor biopsies provide insight into therapeutic targets and evolutionary divergence in relapsed/refractory DLBCL.

Publisher

American Society of Hematology

Subject

Hematology

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