Substrate-bound CCL21 and ICAM1 combined with soluble IL-6 collectively augment the expansion of antigen-specific murine CD4+ T cells-Reference-Cited by-同舟云学术

Substrate-bound CCL21 and ICAM1 combined with soluble IL-6 collectively augment the expansion of antigen-specific murine CD4+ T cells

Published:2017-06-15 Issue:15 Volume:1 Page:1016-1030
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Adutler-Lieber Shimrit¹,Zaretsky Irina²,Sabany Helena³,Kartvelishvily Elena³,Golani Ofra⁴,Geiger Benjamin¹,Friedman Nir²

Affiliation:

1. Department of Molecular Cell Biology,

2. Department of Immunology,

3. Electron Microscopy Unit, and

4. Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel

Abstract

Key Points A synthetic immune niche consisting of CCL21, ICAM1 and IL-6 promoted morphological changes of T cell clusters and increased cell expansion. This synthetic immune niche can serve as an improved approach for efficiently generating antigen-specific immunotherapeutic CD4 T cells.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/15/1016/878584/advances001545.pdf

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