Clinical developments in epigenetic-directed therapies in acute myeloid leukemia

Author:

Pan Darren1,Rampal Raajit2,Mascarenhas John3ORCID

Affiliation:

1. Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY;

2. Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY; and

3. Adult Leukemia Program, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY

Abstract

AbstractAcute myeloid leukemia (AML) is a highly heterogeneous disease arising from acquired genetic and epigenetic aberrations which stifle normal development and differentiation of hematopoietic precursors. Despite the complex and varied biological underpinnings, induction therapy for AML has remained fairly uniform over 4 decades and outcomes remain poor for most patients. Recently, enhanced understanding of the leukemic epigenome has resulted in the translational investigation of a number of epigenetic modifying agents currently in various stages of clinical development. These novel therapies are based on mechanistic rationale and offer the potential to improve AML patient outcomes. In light of many recent advances in this field, we provide an updated, clinically oriented review of the evolving landscape of epigenetic modifying agents for the treatment of AML.

Publisher

American Society of Hematology

Subject

Hematology

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