Regulation of the maturation of human monocytes into immunosuppressive macrophages-Reference-Cited by-同舟云学术

Regulation of the maturation of human monocytes into immunosuppressive macrophages

Published:2017-12-04 Issue:26 Volume:1 Page:2510-2519
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Bayik Defne¹,Tross Debra¹,Haile Lydia A.²,Verthelyi Daniela²,Klinman Dennis M.¹

Affiliation:

1. Cancer and Inflammation Program, National Cancer Institute, National Institutes of Health, Frederick MD; and

2. Laboratory of Immunology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD

Abstract

Key Points NF-κB and Akt regulate human monocyte into macrophage differentiation; p38 MAPK and PTGS2 promote the generation of suppressive macrophage. The Toll-like receptor 2/1 agonist PAM3 induces human monocytes to mature into immunosuppressive macrophages in vitro and in vivo.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/26/2510/880033/advances011221.pdf

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