Zinc finger–IRF composite elements bound by Ikaros/IRF4 complexes function as gene repression in plasma cell-Reference-Cited by-同舟云学术

Zinc finger–IRF composite elements bound by Ikaros/IRF4 complexes function as gene repression in plasma cell

Published:2018-04-18 Issue:8 Volume:2 Page:883-894
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Ochiai Kyoko¹,Kondo Haruka¹,Okamura Yasunobu²,Shima Hiroki¹,Kurokochi Yuko¹,Kimura Kazumi³,Funayama Ryo⁴⁵,Nagashima Takeshi⁴,Nakayama Keiko⁴⁵,Yui Katsuyuki³,Kinoshita Kengo²,Igarashi Kazuhiko¹⁵

Affiliation:

1. Department of Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan;

2. Graduate School of Information Sciences, Tohoku University, Sendai, Japan;

3. Division of Immunology, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan; and

4. Division of Cell Proliferation, United Centers for Advanced Research and Translational Medicine, and

5. Center for Regulatory Epigenome and Diseases, Tohoku University Graduate School of Medicine, Sendai, Japan

Abstract

Key Points The Ikaros/IRF4 complex represses Ebf1 expression by binding to composite elements within the locus. Ezh2 expression is induced by the Batf/IRF4 complex and the Ebf1-Pax5-Bach2 axis.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/2/8/883/880791/advances010413.pdf

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