Sipa1 deficiency–induced bone marrow niche alterations lead to the initiation of myeloproliferative neoplasm-Reference-Cited by-同舟云学术

Sipa1 deficiency–induced bone marrow niche alterations lead to the initiation of myeloproliferative neoplasm

Published:2018-03-07 Issue:5 Volume:2 Page:534-548
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Xiao Pingnan¹²^ORCID,Dolinska Monika¹²,Sandhow Lakshmi¹²,Kondo Makoto¹²,Johansson Anne-Sofie¹²,Bouderlique Thibault¹²,Zhao Ying³⁴²,Li Xidan⁵²,Dimitriou Marios¹²,Rassidakis George Z.⁶²,Hellström-Lindberg Eva¹²^ORCID,Minato Nagahiro⁷²,Walfridsson Julian¹²^ORCID,Scadden David T.⁸⁹²,Sigvardsson Mikael¹⁰¹¹²^ORCID,Qian Hong¹²^ORCID

Affiliation:

1. Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska University Hospital, and

2. Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA;

3. Division of Experimental Cancer Medicine, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden;

4. Clinical Research Center, Karolinska University Hospital Huddinge, Stockholm, Sweden;

5. Integrated Cardio Metabolic Centre, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden;

6. Department of Oncology and Pathology, Karolinska University Hospital, Karolinska Institute, Solna, Sweden;

7. Department of Immunology and Cell Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan;

8. Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA;

9. Harvard Stem Cell Institute, Cambridge, MA;

10. Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden; and

11. Division of Molecular Hematology, Lund University, Lund, Sweden

Abstract

Key Points Sipa1 loss leads to BM niche alterations prior to the initiation of MPN. Sipa1-deficient BM niche induces lethal MPN from normal hematopoietic cells.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/2/5/534/880461/advances013599.pdf

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