Maximum tumor diameter is associated with event-free survival in PET-negative patients with stage I/IIA Hodgkin lymphoma

Author:

Illidge Tim M.12,Phillips Elizabeth H.3ORCID,Counsell Nicholas3,Pettengell Ruth4,Johnson Peter W. M.5ORCID,Culligan Dominic J.6,Popova Bilyana3,Clifton-Hadley Laura3,McMillan Andrew7,Hoskin Peter128ORCID,Barrington Sally F.9ORCID,Radford John12ORCID

Affiliation:

1. Division of Cancer Sciences, University of Manchester, National Institutes of Health Research Biomedical Research Centre Manchester Cancer Research Centre, Manchester, United Kingdom;

2. Christie NHS Foundation Trust, Manchester, United Kingdom;

3. Cancer Research UK and UCL Cancer Trials Centre, University College London, London, United Kingdom;

4. Haemato-oncology, St George's, University of London, London, United Kingdom;

5. Cancer Research UK Centre, University of Southampton, Southampton, United Kingdom;

6. Haematology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom;

7. Haematology, Nottingham City Hospitals NHS Trust, Nottingham, United Kingdom;

8. Clinical Oncology, Mount Vernon Hospital, Middlesex, United Kingdom; and

9. King's College London and Guy's and St Thomas' PET Centre, School of Biomedical Engineering and Imaging Sciences, Kings College London, King's Health Partners, London, United Kingdom

Abstract

Key Points Baseline maximum tumor diameter is an important predictor of relapse for patients with ES-HL achieving complete metabolic remission. Patients with baseline tumor size ≥5 cm have worse outcomes with ABVD alone and are likely to benefit from consolidation radiotherapy.

Publisher

American Society of Hematology

Subject

Hematology

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