Potential impact of complement regulator deficiencies on hemolytic reactions due to minor ABO-mismatched transfusions-Reference-Cited by-同舟云学术

Potential impact of complement regulator deficiencies on hemolytic reactions due to minor ABO-mismatched transfusions

Published:2017-10-11 Issue:23 Volume:1 Page:1977-1982
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Pandey Priyanka¹,Anani Waseem Q.¹,Gottschall Jerome L.¹²,Denomme Gregory A.¹²^ORCID

Affiliation:

1. Diagnostic Laboratories and

2. Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI

Abstract

Key Points An in vitro model shows that hemolysis could be due to the presence of a subclinical PNH clone causing a negative C3b/d DAT. Changes to decay-accelerating factor and membrane inhibitor of reactive lysis may lead to overt hemolysis after minor mismatched transfusions.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/23/1977/878817/advances008805.pdf

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