DNA and factor VII–activating protease protect against the cytotoxicity of histones-Reference-Cited by-同舟云学术

DNA and factor VII–activating protease protect against the cytotoxicity of histones

Published:2017-11-30 Issue:26 Volume:1 Page:2491-2502
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Marsman Gerben¹,von Richthofen Helen¹,Bulder Ingrid¹,Lupu Florea²,Hazelzet Jan³,Luken Brenda M.¹,Zeerleder Sacha¹⁴

Affiliation:

1. Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;

2. Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK;

3. Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands; and

4. Department of Hematology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Abstract

Key Points Free histones, not nucleosomes, are cytotoxic and are degraded by FSAP in serum to protect against cytotoxicity. Free histone H3 was not detectable in sera of septic baboons and patients with meningococcal sepsis.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/26/2491/880154/advances010959.pdf

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4. Extracellular histone release in response to traumatic injury: implications for a compensatory role of activated protein C;Kutcher;J Trauma Acute Care Surg,2012

5. Circulating histones are mediators of trauma-associated lung injury;Abrams;Am J Respir Crit Care Med,2013

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