The SARS-CoV-2 receptor-binding domain preferentially recognizes blood group A-Reference-Cited by-同舟云学术

The SARS-CoV-2 receptor-binding domain preferentially recognizes blood group A

Published:2021-03-03 Issue:5 Volume:5 Page:1305-1309
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Wu Shang-Chuen¹^ORCID,Arthur Connie M.²,Wang Jianmei²,Verkerke Hans²,Josephson Cassandra D.²,Kalman Daniel²^ORCID,Roback John D.²,Cummings Richard D.³,Stowell Sean R.¹³^ORCID

Affiliation:

1. Joint Program in Transfusion Medicine, Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA;

2. Center for Transfusion Medicine and Cellular Therapies, Emory University School of Medicine, Atlanta, GA; and

3. Harvard Glycomics Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

Abstract

Key Points The RBD of SARS-CoV-2 shares sequence similarity with an ancient lectin family known to bind blood group antigens. SARS-CoV-2 RBD binds the blood group A expressed on respiratory epithelial cells, directly linking blood group A and SARS-CoV-2.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/5/5/1305/1801684/advancesadv2020003259.pdf

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