Increased iron export by ferroportin induces restriction of HIV-1 infection in sickle cell disease-Reference-Cited by-同舟云学术

Increased iron export by ferroportin induces restriction of HIV-1 infection in sickle cell disease

Published:2016-12-14 Issue:3 Volume:1 Page:170-183
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Kumari Namita¹,Ammosova Tatiana¹²,Diaz Sharmin¹,Lin Xionghao¹,Niu Xiaomei¹,Ivanov Andrey¹,Jerebtsova Marina³,Dhawan Subhash⁴,Oneal Patricia¹²,Nekhai Sergei¹²³

Affiliation:

1. Center for Sickle Cell Disease,

2. Department of Medicine, and

3. Department of Microbiology, Howard University, Washington, DC; and

4. Division of Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD

Abstract

Key PointsFerroportin reduces intracellular iron, inhibits CDK2 and suppresses SAMHD1 phosphorylation thus inhibiting HIV-1 RT. Ferroportin expression leads to overexpression of IKBα and inhibition of HIV-1 transcription.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/3/170/877971/advances000745.pdf

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