HSC extrinsic sex-related and intrinsic autoimmune disease–related human B-cell variation is recapitulated in humanized mice-Reference-Cited by-同舟云学术

HSC extrinsic sex-related and intrinsic autoimmune disease–related human B-cell variation is recapitulated in humanized mice

Published:2017-10-13 Issue:23 Volume:1 Page:2007-2018
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Borsotti Chiara¹,Danzl Nichole M.¹,Nauman Grace¹,Hölzl Markus A.¹,French Clare¹,Chavez Estefania¹,Khosravi-Maharlooei Mohsen¹,Glauzy Salome²,Delmotte Fabien R.²,Meffre Eric²,Savage David G.³,Campbell Sean R.¹,Goland Robin⁴⁵,Greenberg Ellen⁴⁵,Bi Jing⁶,Satwani Prakash⁷,Yang Suxiao¹,Bathon Joan⁶,Winchester Robert⁶,Sykes Megan¹

Affiliation:

1. Columbia Center for Translational Immunology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY;

2. Department of Immunobiology, Yale University School of Medicine, New Haven, CT;

3. Division of Hematology/Oncology, Department of Medicine,

4. Department of Medicine,

5. Naomi Berrie Diabetes Center, and

6. Division of Rheumatology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY; and

7. Department of Pediatrics, Columbia University, New York, NY

Abstract

Key Points Increased human B-cell reconstitution is seen in female compared to male mice in multiple humanized mouse models. The PI mouse model recapitulates HSC-intrinsic autoimmune defects from T1D and RA bone marrow donors.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/23/2007/878895/advances006932.pdf

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