Erythrocyte β spectrin can be genetically targeted to protect mice from malaria-Reference-Cited by-同舟云学术

Erythrocyte β spectrin can be genetically targeted to protect mice from malaria

Published:2017-12-12 Issue:26 Volume:1 Page:2624-2636
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Lelliott Patrick M.¹,Huang Hong Ming¹,Dixon Matthew W.²,Namvar Arman²³,Blanch Adam J.²,Rajagopal Vijay³,Tilley Leann²,Coban Cevayir⁴,McMorran Brendan J.¹,Foote Simon J.¹,Burgio Gaetan¹

Affiliation:

1. Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia;

2. Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, and

3. Department of Biomedical Engineering, University of Melbourne, Melbourne, VIC, Australia; and

4. Laboratory of Malaria Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan

Abstract

Key Points Mutations in β spectrin cause microcytosis, resulting in increased clearance of erythrocytes and enhanced resistance to malaria in mice. A homozygous CRISPR/Cas9-induced mutation in the binding site between β spectrin and ankyrin-1 increases mouse survival during malaria.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/26/2624/880119/advances009274.pdf

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