Fewer circulating natural killer cells 28 days after double cord blood transplantation predicts inferior survival and IL-15 response-Reference-Cited by-同舟云学术

Fewer circulating natural killer cells 28 days after double cord blood transplantation predicts inferior survival and IL-15 response

Published:2016-12-14 Issue:3 Volume:1 Page:208-218
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Bergerson Rachel J.¹^ORCID,Williams Robin¹,Wang Hongbo¹,Shanley Ryan²,Colbenson Gretchen¹,Kerber Alyssa¹,Cooley Sarah³,Curtsinger Julie M.⁴,Felices Martin³,Miller Jeffrey S.³,Verneris Michael R.¹^ORCID

Affiliation:

1. Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center,

2. Biostatistics and Bioinformatics Core, Masonic Cancer Center,

3. Division of Hematology, Oncology, and Transplantation, Department of Medicine, Masonic Cancer Center, and

4. Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN

Abstract

Key Points Low numbers of reconstituting NK cells at D+28 after dUCBT are associated with inferior DFS. Patients with low NK cell numbers at D+28 have reduced phosphorylation of STAT5 upon IL-15 stimulation and less Eomes expression.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/3/208/877884/advances000158.pdf

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