FLT3-ITD does not predict inferior prognosis in acute myeloid leukemia patients aged ≥60 years

Author:

Shimony Shai12ORCID,Fell Geoffrey3,Chen Evan C.1,Tsai Harrison K.4,Wadleigh Martha1,Winer Eric S.1ORCID,Garcia Jacqueline S.1ORCID,Luskin Marlise R.1ORCID,Stahl Maximilian1,Neuberg Donna S.3,DeAngelo Daniel J.1,Lindsley R. Coleman1ORCID,Stone Richard M.1

Affiliation:

1. 1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

2. 2Rabin Medical Center and Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

3. 3Department of Data Science, Dana-Farber Cancer Institute, Boston, MA

4. 4Department of Pathology, Boston Children’s Hospital, Boston, MA

Publisher

American Society of Hematology

Subject

Hematology

Reference22 articles.

1. Genomic classification and prognosis in acute myeloid leukemia;Papaemmanuil;N Engl J Med,2016

2. Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study;Whitman;Cancer Res,2001

3. Midostaurin plus chemotherapy for acute myeloid leukemia with a FLT3 mutation;Stone;N Engl J Med,2017

4. Gilteritinib or chemotherapy for relapsed or refractory FLT3-mutated AML;Perl;N Engl J Med,2019

5. Azacitidine and venetoclax in previously untreated acute myeloid leukemia;DiNardo;N Engl J Med,2020

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