The MAGIC algorithm probability is a validated response biomarker of treatment of acute graft-versus-host disease

Author:

Srinagesh Hrishikesh K.1ORCID,Özbek Umut2,Kapoor Urvi1,Ayuk Francis3,Aziz Mina1,Ben-David Kaitlyn1,Choe Hannah K.4,DeFilipp Zachariah5ORCID,Etra Aaron1,Grupp Stephan A.6,Hartwell Matthew J.1ORCID,Hexner Elizabeth O.7ORCID,Hogan William J.8,Karol Alexander B.1ORCID,Kasikis Stelios1,Kitko Carrie L.9,Kowalyk Steven1,Lin Jung-Yi2ORCID,Major-Monfried Hannah1,Mielke Stephan1011ORCID,Merli Pietro12ORCID,Morales George1,Ordemann Rainer13,Pulsipher Michael A.14ORCID,Qayed Muna15,Reddy Pavan16,Reshef Ran17ORCID,Rösler Wolf18,Sandhu Karamjeet S.19,Schechter Tal20,Shah Jay1,Sigel Keith1ORCID,Weber Daniela21,Wölfl Matthias22,Wudhikarn Kitsada23ORCID,Young Rachel1,Levine John E.1,Ferrara James L. M.1

Affiliation:

1. Tisch Cancer Institute and

2. Biostatistics Shared Resource Facility, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY;

3. Department of Stem Cell Transplantation, University Medical Center, Hamburg-Eppendorf, Germany;

4. Blood and Marrow Transplantation Program, The Ohio State University Comprehensive Cancer Center, Columbus, OH;

5. Blood and Marrow Transplant Program, Massachusetts General Hospital, Boston, MA;

6. Division of Oncology, Department of Pediatrics, Center for Childhood Cancer Research, Children’s Hospital of Philadelphia and Perelman School of Medicine, and

7. Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA;

8. Blood and Marrow Transplant Program, Division of Hematology, Mayo Clinic, Rochester, MN;

9. Pediatric Blood and Marrow Transplantation Program, Vanderbilt University Medical Center, Nashville, TN;

10. Department of Medicine II, Würzburg University Medical Center, Würzburg, Germany;

11. Cellterapi och Allogen Stamcellstransplantation, Department of Laboratory Medicine, Karolinska University Hospital and Institutet, Stockholm, Sweden;

12. Department of Pediatric Hematology/Oncology, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Pediatrico Bambino Gesù, Rome, Italy;

13. Medical Department 1, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany;

14. Blood and Marrow Transplantation Program, Children’s Hospital Los Angeles, Los Angeles, CA;

15. Pediatric Blood and Marrow Transplantation Program, Aflac Cancer and Blood Disorders Center, Emory University and Children’s Healthcare of Atlanta, Atlanta, GA;

16. Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI;

17. Blood and Marrow Transplantation Program, Columbia University Irving Medical Center, New York, NY;

18. Department of Internal Medicine 5, Hematology/Oncology, University Hospital Erlangen, Erlangen, Germany;

19. Hematology and Hematopoietic Cell Transplant, City of Hope Medical Center, Duarte, CA;

20. Division of Haematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Canada;

21. Blood and Marrow Transplantation Program, University of Regensburg, Regensburg, Germany;

22. Pediatric Blood and Marrow Transplantation Program, Children’s Hospital, University of Würzburg, Würzburg, Germany; and

23. Blood and Marrow Transplantation Program, Chulalongkorn University, Bangkok, Thailand

Abstract

Key Points The MAGIC algorithm probability, computed from 2 serum biomarkers, predicts mortality in all GVHD grades after 4 weeks of treatment. Dynamic changes in the MAGIC algorithm probability occur within all biomarker risk groups and can guide therapy.

Publisher

American Society of Hematology

Subject

Hematology

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