Early quantification of anti-CD19 CAR T cells by flow cytometry predicts response in R/R DLBCL

Author:

Blumenberg Viktoria1234ORCID,Busch Galina2,Baumann Stephan2ORCID,Jitschin Regina56,Iacoboni Gloria78ORCID,Gallur Laura78ORCID,Iraola-Truchuelo Josu7ORCID,Hoster Eva19ORCID,Winkelmann Michael10,Hellwig Konstantin11ORCID,Schmidt Christian1,Frölich Lisa13,Tast Benjamin2,Hildebrand Friederike1,Rejeski Kai1234,Dekorsy Franziska12,Schmidkonz Christian41314,Bäuerle Tobias11,Kunz Wolfgang G.10ORCID,Mougiakakos Dimitrios5615ORCID,Müller Fabian515ORCID,von Bergwelt-Baildon Michael134,Barba Pere78,Bücklein Veit L.124ORCID,Mackensen Andreas515ORCID,Völkl Simon515,Subklewe Marion1234ORCID

Affiliation:

1. 1Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany

2. 2Laboratory for Translational Cancer Immunology, LMU Gene Center, LMU Munich, Munich, Germany

3. 3German Cancer Consortium (DKTK), partner site Munich, Munich, Germany

4. 4Bavarian Center for Cancer Research (BZKF), partner site Munich, Munich, Germany

5. 5Department of Internal Medicine 5, Hematology and Oncology, Friedrich-Alexander-Universität Erlangen-Nürnberg and University Hospital Erlangen, Erlangen, Germany

6. 6Department for Hematology and Oncology, Otto-von-Guericke University, Magdeburg, Germany

7. 7Department of Hematology, Vall d'Hebron University Hospital, Experimental Hematology, Vall d'Hebron Institute of Oncology, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain

8. 8Department of Medicine, Universitat Autònoma of Barcelona, Barcelona, Spain

9. 9Institute for Medical Informatics, Biometry and Epidemiology, LMU Munich, Munich, Germany

10. 10Department of Radiology, LMU University Hospital, LMU Munich, Munich, Germany

11. 11Department of Radiology, Friedrich-Alexander-Universität Erlangen-Nürnberg and University Hospital Erlangen, Erlangen, Germany

12. 12Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany

13. 13Department of Nuclear Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg and University Hospital Erlangen, Erlangen, Germany

14. 14Institute for Medical Engineering, University of Applied Sciences Amberg-Weiden, Weiden, Germany

15. 15Bavarian Cancer Research Center (BZKF), partner site Erlangen, Erlangen, Germany

Publisher

American Society of Hematology

Subject

Hematology

Reference23 articles.

1. GLA/DRST real-world outcome analysis of CAR T-cell therapies for large B-cell lymphoma in Germany;Bethge;Blood,2022

2. Standard-of-care axicabtagene ciloleucel for relapsed or refractory large B-cell lymphoma: results from the US Lymphoma CAR T Consortium;Nastoupil;J Clin Oncol,2020

3. Real-world evidence of brexucabtagene autoleucel for the treatment of relapsed or refractory mantle cell lymphoma;Iacoboni;Blood Adv,2022

4. Value of CT-textural features and volume-based PET parameters in comparison to serologic markers for response prediction in patients with diffuse large B-cell lymphoma undergoing CD19-CAR-T cell therapy;Reinert;J Clin Med,2022

5. Prognostic impact of total metabolic tumor volume in large B-cell lymphoma patients receiving CAR T-cell therapy;Iacoboni;Ann Hematol,2021

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