A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novel RARG-CPSF6 fusion-Reference-Cited by-同舟云学术

A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novel RARG-CPSF6 fusion

Published:2018-06-11 Issue:11 Volume:2 Page:1295-1299
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Miller Christopher A.¹²,Tricarico Christopher¹,Skidmore Zachary L.²,Uy Geoffrey L.¹,Lee Yi-Shan³,Hassan Anjum³,O’Laughlin Michelle D.²,Schmidt Heather²,Tian Ling¹,Duncavage Eric J.³,Griffith Malachi²⁴⁵,Griffith Obi L.¹²⁴⁵,Welch John S.¹⁴,Wartman Lukas D.¹²⁵

Affiliation:

1. Department of Medicine, Washington University School of Medicine, St. Louis, MO;

2. McDonnell Genome Institute, Washington University, St. Louis, MO; and

3. Department of Pathology and Immunology,

4. Department of Genetics, and

5. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO

Abstract

Key Points Novel RARG-CPSF6 fusion in an AML case with promyelocytic features and no evidence of PML-RARA or X-RARA fusion. Gene fusions involving RARG can initiate AML with promyelocytic morphological features.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/2/11/1295/882280/advances014183.pdf

Reference20 articles.

1. Acute promyelocytic leukemia: a review and discussion of variant translocations;Adams;Arch Pathol Lab Med,2015

2. Variations on a theme: the alternate translocations in APL;Redner;Leukemia,2002

3. Retinoic acid receptors: from molecular mechanisms to cancer therapy;di Masi;Mol Aspects Med,2015

4. RARB translocations in acute promyelocytic leukemia without Rara translocation [abstract];Kato;Blood,2017

5. Identification of a novel PML-RARG fusion in acute promyelocytic leukemia;Ha;Leukemia,2017

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