TFPIα interacts with FVa and FXa to inhibit prothrombinase during the initiation of coagulation-Reference-Cited by-同舟云学术

TFPIα interacts with FVa and FXa to inhibit prothrombinase during the initiation of coagulation

Published:2017-12-15 Issue:27 Volume:1 Page:2692-2702
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Wood Jeremy P.¹,Petersen Helle H.²,Yu Bingke³,Wu Xiaoai³,Hilden Ida²,Mast Alan E.¹⁴

Affiliation:

1. Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI;

2. Global Research, Novo Nordisk, Maaloev, Denmark;

3. Discovery Technology China, Novo Nordisk Research Center China, Beijing, China; and

4. Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI

Abstract

Key PointsTFPIα inhibits prothrombinase through interactions with the FXa active site and B-domain acidic region and heavy chain of FXa-activated FVa. Leu252-Thr255 of the TFPIα basic region is necessary for inhibitory activity but not for binding the FXa-activated FVa acidic region.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/27/2692/879463/advances011098.pdf

Reference50 articles.

1. Surface-dependent reactions of the vitamin K-dependent enzyme complexes;Mann;Blood,1990

2. Deficiency of factor Xa-factor Va binding sites on the platelets of a patient with a bleeding disorder;Miletich;Blood,1979

3. A bipartite autoinhibitory region within the B-domain suppresses function in factor V;Bos;J Biol Chem,2012

4. Amino acid region 1000-1008 of factor V is a dynamic regulator for the emergence of procoagulant activity;Wiencek;J Biol Chem,2013

5. Inhibitory sequences within the B-domain stabilize circulating factor V in an inactive state;Zhu;J Biol Chem,2007

Cited by 31 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Factor V variants in bleeding and thrombosis;Research and Practice in Thrombosis and Haemostasis;2024-01

2. Role of tissue factor pathway inhibitor in hormone-induced venous thromboembolism;Blood Coagulation & Fibrinolysis;2023-04-13

3. Post-transcriptional control of haemostatic genes: mechanisms and emerging therapeutic concepts in thrombo-inflammatory disorders;Cardiovascular Research;2023-03-21

4. Tissue factor pathway inhibitor is a potential modifier of bleeding risk in factor XI deficiency;Journal of Thrombosis and Haemostasis;2023-03

5. Assessment of haemostatic function in paediatric surgical patients: ‘if you prick us, do we not bleed?’;British Journal of Anaesthesia;2023-02