Induction of activated T follicular helper cells is critical for anti-FVIII inhibitor development in hemophilia A mice-Reference-Cited by-同舟云学术

Induction of activated T follicular helper cells is critical for anti-FVIII inhibitor development in hemophilia A mice

Published:2019-10-22 Issue:20 Volume:3 Page:3099-3110
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Jing Weiqing¹,Chen Juan¹,Cai Yuanhua¹²,Chen Yingyu¹²,Schroeder Jocelyn A.¹²,Johnson Bryon D.²³⁴⁵⁶,Cui Weiguo¹⁴,Shi Qizhen¹²⁵⁶^ORCID

Affiliation:

1. Blood Research Institute, Versiti, Milwaukee, WI;

2. Department of Pediatrics,

3. Department of Medicine, and

4. Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI;

5. Children’s Research Institute, Children’s Hospital of Wisconsin, Milwaukee, WI; and

6. Midwest Athletes Against Childhood Cancer Fund Research Center, Milwaukee, WI

Abstract

Key Points Anti-FVIII inhibitory antibody development is TFH-cell dependent. FVIII restimulation can specifically induce FVIII-primed TFH-cell proliferation.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/3/20/3099/1502803/advancesadv2019000650.pdf

Reference56 articles.

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5. Vaccinations are not associated with inhibitor development in boys with severe haemophilia A;Platokouki;Haemophilia,2018

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1. The spleen is the major site for the development and expansion of inhibitor producing-cells in hemophilia A mice upon FVIII infusion developing high-titer inhibitor;Thrombosis Research;2023-11

2. Factor IX administration in the skin primes inhibitor formation and sensitizes hemophilia B mice to systemic factor IX administration;Research and Practice in Thrombosis and Haemostasis;2023-11

3. Suppression of anti-drug antibody formation against coagulation factor VIII by oral delivery of anti-CD3 monoclonal antibody in hemophilia A mice;Cellular Immunology;2023-03

4. Hemophilia a patients with inhibitors: Mechanistic insights and novel therapeutic implications;Frontiers in Immunology;2022-12-08

5. Immune tolerance against infused FVIII in hemophilia A is mediated by PD-L1+ Tregs;Journal of Clinical Investigation;2022-11-15