Reduced red blood cell deformability in Plasmodium knowlesi malaria

Author:

Barber Bridget E.123ORCID,Russell Bruce45,Grigg Matthew J.12,Zhang Rou5,William Timothy26,Amir Amirah7,Lau Yee Ling7,Chatfield Mark D.13,Dondorp Arjen M.8,Anstey Nicholas M.12,Yeo Tsin W.29

Affiliation:

1. Global and Tropical Health Division, Menzies School of Health Research, Darwin, NT, Australia;

2. Infectious Diseases Society Sabah–Menzies School of Health Research Clinical Research Unit, Queen Elizabeth Hospital, Kota Kinabalu, Malaysia;

3. Queensland Institute of Medical Research, Brisbane, QLD, Australia;

4. Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand;

5. Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;

6. Jesselton Medical Centre, Kota Kinabalu, Malaysia;

7. Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia;

8. Mahidol Oxford Tropical Medicine Research Unit, Bangkok, Thailand; and

9. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore

Abstract

Key PointsRBC-D is reduced in humans with knowlesi malaria in proportion to disease severity. In humans, but not the macaque hosts, deformability of uRBCs is reduced and is related to the presence of echinocytes.

Publisher

American Society of Hematology

Subject

Hematology

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