Not just a marker: CD34 on human hematopoietic stem/progenitor cells dominates vascular selectin binding along with CD44-Reference-Cited by-同舟云学术

Not just a marker: CD34 on human hematopoietic stem/progenitor cells dominates vascular selectin binding along with CD44

Published:2017-12-26 Issue:27 Volume:1 Page:2799-2816
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

AbuSamra Dina B.¹^ORCID,Aleisa Fajr A.¹^ORCID,Al-Amoodi Asma S.¹^ORCID,Jalal Ahmed Heba M.¹^ORCID,Chin Chee Jia¹,Abuelela Ayman F.¹^ORCID,Bergam Ptissam²,Sougrat Rachid²^ORCID,Merzaban Jasmeen S.¹^ORCID

Affiliation:

1. Cell Migration and Signaling Laboratory, Division of Biological and Environmental Sciences and Engineering, and

2. Imaging and Characterization Core Facility, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia

Abstract

Key Points Human HSPCs expressing CD34 exhibit E-selectin binding activity, whereas those lacking CD34 do not. CD34 is a unique E- and P-selectin ligand on human HSPCs that binds with kinetics comparable to other known selectin ligands.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/27/2799/879408/advances004317.pdf

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