αIIbβ3 binding to a fibrinogen fragment lacking the γ-chain dodecapeptide is activation dependent and EDTA inducible-Reference-Cited by-同舟云学术

αIIbβ3 binding to a fibrinogen fragment lacking the γ-chain dodecapeptide is activation dependent and EDTA inducible

Published:2017-02-22 Issue:7 Volume:1 Page:417-428
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Zafar Hina¹,Shang Yi²,Li Jihong¹,David George A.¹,Fernandez Joseph P.³,Molina Henrik³,Filizola Marta²,Coller Barry S.¹

Affiliation:

1. Allen and Frances Adler Laboratory of Blood and Vascular Biology, The Rockefeller University, New York, NY;

2. Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY; and

3. Proteomics Resource Center, The Rockefeller University, New York, NY

Abstract

Key Points Activation of αIIbβ3 is required for its ancillary site interactions with fibrinogen fragment D lacking the γ-chain dodecapeptide (‘D98’). EDTA can paradoxically induce normal αIIbβ3 to interact with fibrinogen fragment ‘D98.’

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/7/417/878250/advances004689.pdf

Reference72 articles.

1. Interaction of normal, thrombasthenic, and Bernard-Soulier platelets with immobilized fibrinogen: defective platelet-fibrinogen interaction in thrombasthenia;Coller;Blood,1980

2. Integrins: dynamic scaffolds for adhesion and signaling in platelets;Shattil;Blood,2004

3. Fibrinogen competes with von Willebrand factor for binding to the glycoprotein IIb/IIIa complex when platelets are stimulated with thrombin;Gralnick;Blood,1984

4. Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen;Ni;J Clin Invest,2000

5. Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo;Yang;J Thromb Haemost,2006

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