Cost-effectiveness of ibrutinib as first-line therapy for chronic lymphocytic leukemia in older adults without deletion 17p

Author:

Barnes James I.12ORCID,Divi Vasu3,Begaye Adrian4,Wong Russell5,Coutre Steven6,Owens Douglas K.12,Goldhaber-Fiebert Jeremy D.2

Affiliation:

1. Veterans Affairs Palo Alto Health Care System, Palo Alto, CA;

2. Center for Primary Care and Outcomes Research/Center for Health Policy, Department of Medicine, Stanford University School of Medicine,

3. Department of Otolaryngology–Head and Neck Surgery,

4. Stanford University School of Medicine,

5. Department of Management Science and Engineering, and

6. Division of Hematology, Stanford University School of Medicine, Stanford University, Stanford, CA

Abstract

Key Points At current prices, ibrutinib is not a cost-effective initial CLL therapy in older patients without 17p deletion. The cost of ibrutinib would need to be <$6800 per month to be cost-effective.

Publisher

American Society of Hematology

Subject

Hematology

Reference51 articles.

1. Cancer statistics, 2015;Siegel;CA Cancer J Clin,2015

2. National Cancer Institute, Surveillance, Epidemiology, and End Results. Cancer Stat Facts: Leukemia—Chronic Lymphocytic Leukemia (CLL). https://seer.cancer.gov/statfacts/html/clyl.html. Accessed 13 February 2018.

3. Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia;Byrd;N Engl J Med,2013

4. Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia;Byrd;N Engl J Med,2014

5. Ibrutinib as initial therapy for patients with chronic lymphocytic leukemia;Burger;N Engl J Med,2015

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