Alterations in platelet secretion differentially affect thrombosis and hemostasis

Author:

Joshi Smita1ORCID,Banerjee Meenakshi1ORCID,Zhang Jinchao1ORCID,Kesaraju Akhil1,Pokrovskaya Irina D.2,Storrie Brian2,Whiteheart Sidney W.1

Affiliation:

1. Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY; and

2. Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR

Abstract

Key Points VAMP isoforms regulate the kinetics and extent of platelet granule exocytosis. Manipulating platelet sensitive factor attachment protein receptors alters granule secretion, which affects the hemostatic balance.

Publisher

American Society of Hematology

Subject

Hematology

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