Hepatic thrombopoietin gene silencing reduces platelet count and breast cancer progression in transgenic MMTV-PyMT mice-Reference-Cited by-同舟云学术

Hepatic thrombopoietin gene silencing reduces platelet count and breast cancer progression in transgenic MMTV-PyMT mice

Published:2019-10-22 Issue:20 Volume:3 Page:3080-3091
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Shirai Toshiaki¹²,Revenko Alexey S.³^ORCID,Tibbitts Justin⁴,Ngo Anh T. P.¹,Mitrugno Annachiara¹,Healy Laura D.¹^ORCID,Johnson Jennifer¹,Tucker Erik I.¹⁵,Hinds Monica T.¹,Coussens Lisa M.⁴,McCarty Owen J. T.¹,Monia Brett P.³,Gruber András¹⁵^ORCID

Affiliation:

1. Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, OR;

2. Department of Clinical and Laboratory Medicine, School of Medicine, University of Yamanashi, Shimokato, Yamanashi, Japan;

3. Ionis Pharmaceuticals, Carlsbad, CA;

4. Department of Cell, Developmental & Cancer Biology, School of Medicine, Knight Cancer Institute, Oregon Health & Science University, Portland, OR; and

5. Aronora, Inc, Portland, OR

Abstract

Key pointsAntisense oligonucleotide targeting of hepatic THPO gene expression reduces platelet count within the hemostatic range in mice and baboons. THPO gene silencing suppresses spontaneous metastatic mammary gland carcinoma progression in transgenic MMTV-PyMT mice.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/3/20/3080/1502814/advancesadv2019000250.pdf

Reference61 articles.

1. Contribution of platelets to tumour metastasis;Gay;Nat Rev Cancer,2011

2. Platelets and cancer;Nash;Lancet Oncol,2002

3. Paraneoplastic thrombocytosis in ovarian cancer [published correction appears in N Engl J Med. 2012;367(18):1768];Stone;N Engl J Med,2012

4. Cancer and platelet crosstalk: opportunities and challenges for aspirin and other antiplatelet agents;Xu;Blood,2018

5. Thrombopoietin: the primary regulator of platelet production;Kaushansky;Blood,1995

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