Systemic multilineage engraftment in mice after in utero transplantation with human hematopoietic stem cells-Reference-Cited by-同舟云学术

Systemic multilineage engraftment in mice after in utero transplantation with human hematopoietic stem cells

Published:2018-01-05 Issue:1 Volume:2 Page:69-74
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Witt Russell G.¹²,Kreger Emily M.¹²,Buckman Laura B.³,Moradi Patriss W.¹,Ho Phong T.³,Derderian S. Christopher¹²,Tsai Perry³,Baker Chris¹²,Schramm Nathaniel³,Cleary Rachel³,Garcia J. Victor³,MacKenzie Tippi C.¹²

Affiliation:

1. Eli and Edythe Broad Center of Regeneration Medicine, San Francisco, CA;

2. Department of Surgery, University of California, San Francisco, San Francisco, CA; and

3. Division of Infectious Diseases, Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC

Abstract

Key Points IUHCT of human cord blood–derived CD34+ cells into fetal NSG mice results in systemic multilineage engraftment with human cells. Preconditioning with in utero injection of an anti-c-Kit receptor antibody (ACK2) results in an improved rate of engraftment.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/2/1/69/879606/advances011585.pdf

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