Replacing mouse BAFF with human BAFF does not improve B-cell maturation in hematopoietic humanized mice-Reference-Cited by-同舟云学术

Replacing mouse BAFF with human BAFF does not improve B-cell maturation in hematopoietic humanized mice

Published:2017-12-19 Issue:27 Volume:1 Page:2729-2741
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Lang Julie¹,Zhang Bicheng²,Kelly Margot¹,Peterson Jacob N.¹,Barbee Jacob¹,Freed Brian M.³,Di Santo James P.⁴⁵,Matsuda Jennifer L.²,Torres Raul M.¹²,Pelanda Roberta¹²

Affiliation:

1. Department of Immunology and Microbiology, School of Medicine, University of Colorado Denver, Aurora, CO;

2. Department of Biomedical Research, National Jewish Health, Denver, CO;

3. Division of Allergy and Clinical Immunology, School of Medicine, University of Colorado Denver, Aurora, CO;

4. Innate Immunity Unit, Institut Pasteur, Paris, France; and

5. U1223, INSERM, Paris, France

Abstract

Key Points Expression of full-length hBAFF from cDNA in the endogenous murine locus does not improve maturation of human B cells in hu-mice. mBAFF is not limiting the maturation of human B cells in hu-mice.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/27/2729/879348/advances010090.pdf

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