Replication timing alterations in leukemia affect clinically relevant chromosome domains

Author:

Rivera-Mulia Juan Carlos1ORCID,Sasaki Takayo2,Trevilla-Garcia Claudia1,Nakamichi Naoto3,Knapp David J. H. F.3ORCID,Hammond Colin A.3,Chang Bill H.4ORCID,Tyner Jeffrey W.56,Devidas Meenakshi7ORCID,Zimmerman Jared2,Klein Kyle N.2,Somasundaram Vivek2,Druker Brian J.4ORCID,Gruber Tanja A.8,Koren Amnon9,Eaves Connie J.3,Gilbert David M.210

Affiliation:

1. Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Medical School, Minneapolis, MN;

2. Department of Biological Science, Florida State University, Tallahassee, FL;

3. Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada;

4. Division of Pediatric Hematology and Oncology, Department of Pediatrics,

5. Division of Hematology and Medical Oncology, Department of Medicine, Oregon Health & Science University Knight Cancer Institute, and

6. Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR;

7. Department of Biostatistics, College of Medicine, College of Public Health and Health Professions, University of Florida, Gainesville, FL;

8. Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN;

9. Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY; and

10. Center for Genomics and Personalized Medicine, Florida State University, Tallahassee, FL

Abstract

Key Points DNA replication timing of >100 pediatric leukemic samples identified BCP-ALL subtype-specific genome alteration signatures. Comparative analyses identified features of specific stages of B-cell differentiation and potential associations with clinical outcome.

Publisher

American Society of Hematology

Subject

Hematology

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