TAZ functions as a tumor suppressor in multiple myeloma by downregulating MYC-Reference-Cited by-同舟云学术

TAZ functions as a tumor suppressor in multiple myeloma by downregulating MYC

Published:2019-11-19 Issue:22 Volume:3 Page:3613-3625
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Grieve Stacy¹^ORCID,Wajnberg Gabriel²^ORCID,Lees Miranda¹,Chacko Simi²,Weir Jackson¹,Crapoulet Nicolas²,Reiman Tony¹³⁴

Affiliation:

1. Department of Biology, University of New Brunswick, Fredericton, NB, Canada;

2. Atlantic Cancer Research Institute, Moncton, NB, Canada;

3. Department of Oncology, Saint John Regional Hospital, Saint John, NB, Canada; and

4. Department of Medicine, Dalhousie University, Saint John, NB, Canada

Abstract

Key PointsExpression of Hippo component TAZ is downregulated in MM through hypermethylation. TAZ reexpression, exogenously or pharmacologically, causes apoptosis and enhances sensitivity to anti-MM therapies by downregulating MYC.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/3/22/3613/1541180/advancesadv2019000374.pdf

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