Immune rebound associates with a favorable clinical response to autologous HSCT in systemic sclerosis patients

Author:

Arruda Lucas C. M.12ORCID,Malmegrim Kelen C. R.23ORCID,Lima-Júnior João R.24,Clave Emmanuel56,Dias Juliana B. E.7,Moraes Daniela A.7,Douay Corinne5,Fournier Isabelle5,Moins-Teisserenc Hélène56,Alberdi Antônio José68,Covas Dimas T.27,Simões Belinda P.27,Lansiaux Pauline9,Toubert Antoine56ORCID,Oliveira Maria Carolina127ORCID

Affiliation:

1. Basic and Applied Immunology Program, Ribeirão Preto Medical School,

2. Center for Cell-based Therapy, Regional Hemotherapy Center of the Ribeirão Preto Medical School,

3. Department of Clinical, Toxicological and Bromatological Analysis, School of Pharmaceutical Sciences of Ribeirão Preto, and

4. Graduate Program on Bioscience Applied to Pharmacy, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil;

5. INSERM Unité Mixte de Recherche 1160, Institut Universitaire d’Hématologie, Hôpital Saint-Louis, Assistance Publique–Hôpitaux de Paris (AP-HP), Paris, France;

6. Institut Universitaire d'Hématologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France;

7. Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil;

8. Plateforme Technologique, Institut Universitaire d'Hématologie, Paris, France; and

9. Unité de Médecine Interne, Maladies Autoimmunes et Pathologie Vasculaire, UF 04, AP-HP, Centre de référence des maladies auto-immunes systémiques rares d’Ile-de-France (site constitutif), FAI2R, Hôpital Saint-Louis, Paris, France

Abstract

Key Points Clinical response of SSc patients after AHSCT is associated with thymic and bone marrow rebounds. Responder patients showed higher Treg and Breg counts and lower pre-/post-AHSCT TCR repertoire overlap than nonresponder patients.

Publisher

American Society of Hematology

Subject

Hematology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3