Clinicopathologic consensus study of gray zone lymphoma with features intermediate between DLBCL and classical HL

Author:

Pilichowska Monika1,Pittaluga Stefania2,Ferry Judith A.3,Hemminger Jessica4,Chang Hong56,Kanakry Jennifer A.5,Sehn Laurie H.7,Feldman Tatyana8,Abramson Jeremy S.9,Kritharis Athena9,Hernandez-Ilizaliturri Francisco J.10,Lossos Izidore S.11,Press Oliver W.12,Fenske Timothy S.13,Friedberg Jonathan W.14,Vose Julie M.15,Blum Kristie A.16,Jagadeesh Deepa17,Woda Bruce18,Gupta Gaurav K.1,Gascoyne Randy D.7,Jaffe Elaine S.2,Evens Andrew M.19ORCID

Affiliation:

1. Department of Pathology and Laboratory Medicine, Tufts Medical Center, Boston, MA;

2. Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;

3. Department of Pathology, Massachusetts General Hospital, Boston, MA;

4. Department of Pathology, Wexner Medical Center, The Ohio State University, Columbus, OH;

5. Division of Hematology/Oncology, Johns Hopkins University School of Medicine, Baltimore, MD;

6. Institute for Clinical Research and Health Policy Studies and the Biostatistics, Epidemiology, and Research Design Center, Tufts Medical Center, Boston, MA;

7. Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC, Canada;

8. Hackensack University Medical Center, Hackensack, NJ;

9. Hematology/Oncology, Massachusetts General Hospital Cancer Center, Boston, MA;

10. Roswell Park Cancer Institute, Buffalo, NY;

11. Division of Hematology/Oncology, University of Miami School of Medicine, Miami, FL;

12. Fred Hutchinson Cancer Research Center, Seattle, WA;

13. Division of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI;

14. Division of Hematology/Oncology, University of Rochester, Rochester, NY;

15. University of Nebraska Medical Center, Omaha, NE;

16. Division of Hematology, The Ohio State University, Columbus, OH;

17. Cleveland Clinic, Cleveland, OH;

18. Department of Pathology, University of Massachusetts Medical School, Worcester, MA; and

19. Division of Hematology/Oncology, Tufts Medical Center, Boston, MA

Abstract

Key PointsAccurate GZL diagnosis remains challenging, with >60% of patients with presumed GZL having the diagnosis reclassified on consensus review. Treatment with DLBCL-based therapy appears most effective for GZL (including R-CHOP); however, new therapies are needed to improve outcomes.

Publisher

American Society of Hematology

Subject

Hematology

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