Non-del(5q) myelodysplastic syndromes–associated loci detected by SNP-array genome-wide association meta-analysis

Author:

McGraw Kathy L.1ORCID,Cheng Chia-Ho2,Chen Y. Ann2,Hou Hsin-An3,Nilsson Björn4,Genovese Giulio567ORCID,Cluzeau Thomas8,Pellagatti Andrea9ORCID,Przychodzen Bartlomiej P.10,Mallo Mar11,Arenillas Leonor12ORCID,Mohamedali Azim13,Adès Lionel14,Sallman David A.1,Padron Eric1,Sokol Lubomir1,Moreilhon Chimene8,Raynaud Sophie8,Tien Hwei-Fang3,Boultwood Jacqueline9ORCID,Ebert Benjamin L.15,Sole Francesc11ORCID,Fenaux Pierre14,Mufti Ghulam J.13,Maciejewski Jaroslaw P.10,Kanetsky Peter A.16ORCID,List Alan F.1

Affiliation:

1. Department of Malignant Hematology and

2. Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL;

3. Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan;

4. Department of Laboratory Medicine, Section of Hematology and Transfusion Medicine, Lund University, Lund, Sweden;

5. Stanley Center for Psychiatric Research and

6. Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA;

7. Department of Genetics, Harvard Medical School, Boston, MA;

8. Cote d’Azur University, Centre Hospitalier Universitaire of Nice, Nice, France;

9. Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford and Oxford Biomedical Research Centre Haematology Theme, Oxford, United Kingdom;

10. Cleveland Clinic, Taussig Cancer Institute, Cleveland, OH;

11. Institut de Recerca Contra la Leucèmia Josep Carreras, Institut Catala d'Oncologia–Hospital GermansTrias i Pujol, Universitat Autonòma de Barcelona, Badalona, Barcelona, Spain;

12. Laboratori de Citologia Hematòlogica, Servei de Patologia, Hospital del Mar, Barcelona, Spain;

13. Department of Haematological Medicine, Kings College London, London, United Kingdom;

14. Senior Hematology Department, Hopital Saint Louis, Paris, France;

15. Departments of Medicine and Medical Oncology, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA; and

16. Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL

Abstract

Key Points We report here the findings from the first known MDS genome-wide association study and meta-analysis identifying 8 unique loci. Genes harboring suggested MDS-associated loci, including EYA2, are innate immune regulators and may have clinical and biological relevance.

Publisher

American Society of Hematology

Subject

Hematology

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