IL-33, IL-25, and TSLP induce a distinct phenotypic and activation profile in human type 2 innate lymphoid cells

Abstract

Key Points IL-25, IL-33, and TSLP induce distinct activation profiles in ILC2s. IL-2 further amplifies their response and induces an NK-like phenotype. ILC2 plasticity is observed in serum-free media even when in the presence of IL-25, IL-33, and TSLP, and absence of either IL-1β or IL-12.