Telomere shortening correlates with leukemic stem cell burden at diagnosis of chronic myeloid leukemia

Author:

Bouillon Anne-Sophie1,Ventura Ferreira Monica S.1,Awad Shady Adnan2,Richter Johan3,Hochhaus Andreas4,Kunzmann Volker5,Dengler Jolanta6,Janssen Jeroen7,Ossenkoppele Gert7,Westerweel Peter E.8,te Boekhorst Peter A. W.9,Mahon Francois-Xavier10,Hjorth-Hansen Henrik11,Isfort Susanne1,Fioretos Thoas12,Hummel Sebastian1,Schemionek Mirle1,Wilop Stefan1,Koschmieder Steffen1,Saußele Susanne13,Mustjoki Satu2,Beier Fabian1,Brümmendorf Tim H.1

Affiliation:

1. Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany;

2. Hematology Research Unit, Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland;

3. Department of Hematology, Oncology, and Radiation Physics, Skane University Hospital, Lund, Sweden;

4. Klinik für Innere Medizin II, Universitätsklinikum Jena, Jena, Germany;

5. Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany;

6. Onkologische Schwerpunktpraxis, Heilbronn, Germany;

7. Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands;

8. Department of Hematology, Albert Schweitzer Hospital, Dordrecht, The Netherlands;

9. Department of Hematology, Erasmus MC, Rotterdam, The Netherlands;

10. Hematology Laboratory, Haut-Lévêque Hospital, Bordeaux University Hospital, Bordeaux, France;

11. Department of Hematology, St. Olavs Hospital, Norwegian University of Science and Technology, Trondheim, Norway;

12. Department of Clinical Genetics, Skane University Hospital, Lund, Sweden; and

13. Internal Medicine III, University of Heidelberg at Mannheim, Mannheim, Germany

Abstract

Key Points TL in LSCs is significantly shortened at diagnosis of CML and correlates with LSC burden. TL in nonleukemic myeloid cells in deep molecular remission is unaffected by long-term TKI treatment.

Publisher

American Society of Hematology

Subject

Hematology

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