Patient-derived antibody recognizes a unique CD43 epitope expressed on all AML and has antileukemia activity in mice-Reference-Cited by-同舟云学术

Patient-derived antibody recognizes a unique CD43 epitope expressed on all AML and has antileukemia activity in mice

Published:2017-08-18 Issue:19 Volume:1 Page:1551-1564
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Gillissen Marijn A.¹²,de Jong Greta¹²,Kedde Martijn¹,Yasuda Etsuko¹,Levie Sophie E.¹,Moiset Gemma¹,Hensbergen Paul J.³,Bakker Arjen Q.¹,Wagner Koen¹,Villaudy Jullien¹,van Helden Pauline M.¹,Spits Hergen¹⁴,Hazenberg Mette D.²⁴

Affiliation:

1. AIMM Therapeutics, Amsterdam, The Netherlands;

2. Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands;

3. Center for Proteomics and Metabolomics, University Medical Center, Leiden, The Netherlands; and

4. Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands

Abstract

Key Points AT1413 is a monoclonal antibody isolated from a cured patient with AML that recognizes CD43s, a novel epitope expressed by AML and MDS blasts. AT1413 eliminates CD43s-expressing leukemic blasts in vitro and in vivo and may have potential as a therapeutic antibody.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/19/1551/877959/advances008342.pdf

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