CLL dedifferentiation to clonally related myeloid cells

Author:

Dong Qianze123,Xiu Yan123,Bossler Aaron1,Syrbu Sergei1,Wang Hongming14,Xue Weishuang15,Zhao Jinming126,Li Qingchang6,Jin Meiling7,Wang Lili7,Boyce Brendan8,Sakr Hany23ORCID,Ansari Mohammad Q.3,Zhao Chen1239

Affiliation:

1. Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA;

2. Department of Pathology, Case Western Reserve University, Cleveland, OH;

3. Department of Pathology, Louis Stokes Veterans Affairs Medical Center, Cleveland, OH;

4. Department of Otolaryngology and

5. Department of Neurology, First Affiliated Hospital of China Medical University, Shenyang Shi, Liaoning Sheng, China;

6. Department of Pathology, China Medical University, Shenyang Shi, Liaoning Sheng, China;

7. Department of Systems Biology, Beckman Research Institute, City of Hope, Monrovia, CA;

8. Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY; and

9. Department of Pathology, University Hospitals Case Medical Center, Cleveland, OH

Abstract

Key Points Common progenitor cells exist in clonally related concomitant chronic lymphocytic leukemia and acute myeloid leukemias. CLL cells dedifferentiated to clonally related myeloid cells posttransplantation.

Publisher

American Society of Hematology

Subject

Hematology

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