Pharmacologic control of CAR-T cell function using dasatinib-Reference-Cited by-同舟云学术

Pharmacologic control of CAR-T cell function using dasatinib

Published:2019-02-27 Issue:5 Volume:3 Page:711-717
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Weber Evan W.¹,Lynn Rachel C.¹,Sotillo Elena¹,Lattin John¹,Xu Peng¹,Mackall Crystal L.¹²³

Affiliation:

1. Stanford Cancer Institute,

2. Department of Pediatrics, and

3. Department of Medicine, Stanford University School of Medicine, Stanford, CA

Abstract

Key Points Dasatinib potently and reversibly suppresses CAR-T cell cytotoxicity, cytokine secretion, and proliferation. Dasatinib could be repurposed as a safety switch to mitigate CAR-mediated toxicity in patients.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/3/5/711/1631325/advances028720.pdf

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