The number of CD56dim NK cells in the graft has a major impact on risk of disease relapse following allo-HSCT-Reference-Cited by-同舟云学术

The number of CD56dim NK cells in the graft has a major impact on risk of disease relapse following allo-HSCT

Published:2017-08-21 Issue:19 Volume:1 Page:1589-1597
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Maggs Luke¹,Kinsella Francesca¹²,Chan Y. L. Tracey¹,Eldershaw Suzy¹,Murray Duncan¹,Nunnick Jane²,Bird Joanne²,Craddock Charles²,Zuo Jianmin¹,Malladi Ram¹²,Moss Paul¹²

Affiliation:

1. Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom; and

2. Birmingham Health Partners, Department of Haematology, Queen Elizabeth Hospital, Birmingham, United Kingdom

Abstract

Key Points A stem cell graft NK cell dose below 6.3 × 106 cells per kg associates with risk of disease relapse following T-cell–depleted allo-HSCT. Clinical outcomes of patients undergoing allo-HSCT may be improved by setting an NK cell threshold within donor stem cell grafts.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/19/1589/877944/advances008631.pdf

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