Complement-mediated thrombotic microangiopathy associated with lupus nephritis

Author:

Park Mi Hee1ORCID,Caselman Nicholas1,Ulmer Scott2,Weitz Ilene Ceil13ORCID

Affiliation:

1. Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA;

2. Hematology/Oncology, South Texas Accelerated Research and Therapeutics (START) Center for Cancer Care, San Antonio, TX; and

3. Jane Anne Nohl Division of Hematology, Keck School of Medicine, University of Southern California, Los Angeles, CA

Abstract

Key Points CM-TMA is a unique subset of patient with LN. CM-TMA in LN is responsive to complement inhibition with eculizumab.

Publisher

American Society of Hematology

Subject

Hematology

Reference28 articles.

1. Syndromes of thrombotic microangiopathy;George;N Engl J Med,2014

2. The use of ADAMTS13 activity, platelet count, and serum creatinine to differentiate acquired thrombotic thrombocytopenic purpura and other thrombotic microangiopathies;Cataland;Br J Haematol,2012

3. Drug-induced thrombotic microangiopathy: experience of the Oklahoma Registry and the BloodCenter of Wisconsin;Reese;Am J Hematol,2015

4. Effective treatment of chemotherapy induced atypical haemolytic uraemic syndrome: a case series of 7 treated patients [published online ahead of print 31 August 2017];Weitz;Br J Haematol

5. Inclusion of renal vascular lesions in the 2003 ISN/RPS system for classifying lupus nephritis improves renal outcome predictions;Wu;Kidney Int,2013

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